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KMID : 0882420110810010017
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Korean Journal of Medicine
2011 Volume.81 No. 1 p.17 ~ p.25
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The Effects on Nutrition, Metabolism and Infection by Proton Pump Inhibitors: Unsafe Perspective
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Cha Bong-Ki
Choi Chang-Hwan
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Abstract
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Proton pump inhibitors (PPI) are very effective drug used frequently in acid-related disorders. Long-term use of PPI is becoming increasingly common, often without appropriate indications. The debate had focused on the adverse effects related to long-term use of PPI during the last years. This article is a detailed review of the evidence on this topic, focusing on the adverse effects of long-term PPI use that have developed the greatest concern; vitamin B12 deficiency, iron deficiency, impaired calcium absorption, bony fracture, hypomagnesemia, increased susceptibility to pneumonia and enteric infections. Although PPIs have been used with a high margin of safety, the clinicians should consider reducing the dose of PPIs and reassessing the treatment duration to prevent adverse effects of PPIs.
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KEYWORD
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Proton pump inhibitors, Adverse effects
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